The college began its first few years as one of the first Maktab Rendah Sains MARA to be established by the organization in 1972. 150 male students from all over Malaysia were enrolled in the college in its first intake. During this time, the institution offers only the standard Malaysian curriculum for secondary students ranging from Form 1 to Form 5. The programme ended in 1985.
In 1978, the college introduced the University Kebangsaan Malaya Science Matriculation Programme. It ran concurrently with the existing secondary school curriculum.
1985 - 1988
The college then introduced the GCE A-Levels programme in 1985, however the programme ceased in 1988.
The college has introduced yet another programme in 1988, which is the Northen Consortium University Degree Programme.
The college has changed its name to Kolej Pengajian Tinggi MARA, or MARA Higher Education College, and was under the administration of Yayasan Pelajaran MARA. MARA took over the administration in 1992, and has reinstated the UKM Matriculation Programme with the addition of two additional courses, which are Science and Accounting.
The college became formally known as Kolej MARA Seremban on the 3rd of February 1994.
In the year 2000, The UKM Matriculation Programme was abolished to make way for the Malaysian Education Ministry Matriculation Programme. This change was made as the Ministry of Education Malaysia took over all matriculation programmes in the country to unify the curriculum. The programme ended on the 14th of April 2005.
The GCE A Levels programme was reinstated in 2002, and is still being offered by the college presently.
The college gained the International Baccalaurate World School certification and was authorized to offer the IB Diploma Programme in April 2005.
The college was then put under the administration of a sub division of MARA, the MARA Higher Education Department on the 11th of January 2007.
The college now prides itself as it is one of the few institutions in Malaysia that offers both A Level and the IB Diploma Programme. It has also sent many students overseas to further their studies.